Thursday, April 2, 2020

an inconclusive little Chinese clinical trial

Must Read

in the United States, the coalition of skeptics is losing ground in the face of the epidemic

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, at a White House press...

in Israeli hospitals, Arabs at the forefront

Medical personnel from the quarantine room at Shaare Zedek Hospital in Jerusalem on March 24. YONATAN SINDEL...

South Korea finds coronavirus sick with cults

The father of a follower of the Shincheonji Church of Jesus is holding "Chassons Shincheonji" signs at...

In front of a pharmacy, in Nice, on March 23, 2020. ERIC GAILLARD / REUTERS

Correspondence published in the journal Lancet Global Health March 19 reported on a Chinese clinical trial of hydroxychloroquine, presenting it as "Having shown positive preliminary results (although not conclusive due to the small sample size)".

Article reserved for our subscribers Read also Coronavirus: chloroquine tested with caution in China

On closer inspection, the results in question are far from convincing. This clinical trial was carried out by researchers from Shanghai on 30 patients with mild symptoms of Covid-19. The objective was to compare the presence or absence of virus seven days after the start of treatment, consisting of 400 mg / day of hydroxychloroquine – the molecule recommended in France by Professor Didier Raoult (IHU Méditerranée Infections, Marseille), in combination with an antibiotic, to treat Covid-19.

In France, "The High Council recommends not to use this treatment in the absence of a recommendation, except for severe, hospital forms on the collegial decision of doctors and under strict medical supervision", recalled the Minister of Health, Olivier Véran.

Difficult to interpret results

The results of the Chinese clinical study, published in the Journal of Zhejiang University, show that if the virus has disappeared in 87% of treated patients, this percentage rises to 93% in the control group who did not receive this molecule. The median length of hospital stay until disappearance of the virus in the samples is considered to be statistically comparable in the two groups, but it was four days (in a range of one to nine) in patients who received hydroxychloroquine, against two (range from one to four days) in untreated people.

Article reserved for our subscribers Read also Coronavirus: how the scientific community is mobilizing

The only advantage of hydroxychloroquine compared to the absence of specific treatment: the development of pulmonary involvement, which was observed on radiography only in 33% of treated patients, against 47% in controls. Five cases against seven, which remains difficult to interpret.

These results lead Chinese researchers to conclude that the prognosis in patients "Common" (non-severe cases) is " Well ", regardless of treatment. But they admit that it will take a larger study to assess the value of hydroxychloroquine against Covid-19.

Our selection of articles on the coronavirus

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Latest News

in the United States, the coalition of skeptics is losing ground in the face of the epidemic

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, at a White House press...

in Israeli hospitals, Arabs at the forefront

Medical personnel from the quarantine room at Shaare Zedek Hospital in Jerusalem on March 24. YONATAN SINDEL / FLASH90In Israel, the heroes...

South Korea finds coronavirus sick with cults

The father of a follower of the Shincheonji Church of Jesus is holding "Chassons Shincheonji" signs at a rally in Seoul on...

Washington launches massive drug operation in Latin America, despite coronavirus

Defense Minister Mark Esper at the White House daily coronavirus briefing on April 1. MANDEL NGAN / AFPWhile the US military is...

The death of Abdel Halim Khaddam, former Syrian vice-president

Former Syrian vice-president Abdel-Halim Khaddam, in Brussels, in 2011. Thierry Roge / REUTERSFormer Syrian vice-president Abdel Halim Khaddam, who served Baathist rule...

More Articles Like This